|
KMID : 1009020140120030215
|
|
Clinical Psychopharmacology and Neuroscience
2014 Volume.12 No. 3 p.215 ~ p.217
|
|
|
Effects of Add-on Ramelteon on Cognitive Impairment in Patients with Schizophrenia: An Open-label Pilot Trial
|
|
Yukihiko Shirayama
Michio Takahashi
Masatoshi Suzuki
Yoshiaki Tsuruoka
Koichi Sato
|
|
|
Abstract
|
|
|
Objective : This open-label study examined the effects of ramelteon on cognitive functions in 10 outpatients with schizophrenia.
Methods : Ramelteon (8 mg/day) was administered to 10 patients with schizophrenia for six months. The verbal fluency test, Trail-Making Test, the Wisconsin Card Sorting Test, the Stroop Test, the Digit Span Distraction Test, Iowa Gambling Task, the Rey Auditory Verbal Learning Test were evaluated at baseline and 6 months after treatment with ramelteon.
Results : Ramelteon improved significantly the scores of Rey Auditory Verbal Learning Test. Additionally, ramelteon exerted improvements in the verbal fluency and Iowa Gambling Task in 4 patients.
Conclusion : Ramelteon could be a potential therapeutic drug, in adjunctive treatment of learning and memory deficits seen in patients with schizophrenia.
|
|
|
KEYWORD
|
|
|
Ramelteon, Schizophrenia, Verbal learning
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|